Obstructive sleep apnea severity associated with increased Aβ burden in the hippocampus

Takeaway

  • Obstructive sleep apnea (OSA) severity significantly predicts amyloid beta (Aβ) plaque burden, but not neurofibrillary tangle burden (NFT), in the hippocampus.

Why this matters ?

    The results of this study may account for the misclassification of cognitively unimpaired individuals with untreated sleep apnea, currently considered to be in the pre-symptomatic stage of Alzheimer’s disease.