Off-label amyotrophic lateral sclerosis treatment found ineffective


  • Penicillin G/Hydrocortisone (PenGH), increasingly used off-label as a treatment for amyotrophic lateral sclerosis (ALS), does not stop disease progression and intravenous administration may increase risk of thrombosis.

Why this matters

    PenGH should be discontinued as an off-label treatment of ALS given the lack of therapeutic rationale.