Ophthalmic biomarkers of intracranial pressure


  • Ophthalmic biomarkers and brain magnetic resonance imaging (MRI) are promising non-invasive indicators of intracranial pressure (ICP). Patients with several abnormal ophthalmic biomarkers or a combination of abnormal MRI and ophthalmic markers should have a very high suspicion of intracranial hypertension.

Why this matters

  • Despite the investigation of several non-invasive techniques, invasive intracranial measurements remain the standard practice for measuring ICP.

  • Patients with suspected intracranial hypertension in elective care often receive brain MRIs and ophthalmic assessments. Several brain and ophthalmic measurements have been proposed as biomarkers of ICP, but not comprehensively tested.