Orbitofrontal neurons can acquire and maintain long-term memory to guide behavioral adaption


  • The orbitofrontal cortex (OFC) has several functional clusters of neurons that distinctly encode cue-reward memory representations, were maintained by the same neurons after extinction of cue-reward pairing, and also supported behavioral learning and memory, leading to the conclusion that OFC neuronal activity represents a long-term cue-reward associative memory to support behavioral adaption.

Why this matters

  • Although studying the neuronal network basis of learning and memory has been difficult in deep brain areas, these results indicate that the complexity of OFC neuronal function might be a result from distinct neuronal subpopulations within that contribute to distinct functions.