Outcomes of gamma-knife surgery for hypothalamic hamartoma resection


  • Resection of hypothalamic hamartoma (HH) by gamma-knife surgery (GKS) in epileptic patients is associated with reduced seizure frequency and improved cognitive outcomes.

Why this matters

  • Early surgical resection can improve or cure HH-associated epilepsy and cognitive and psychiatric comorbidities.

  • Even with minimally invasive techniques there is a risk of memory impairment or cognitive decline following HH resection surgery; however cognitive outcomes with some types of surgery – including GKS – have not yet been studied.