Outcomes of intravenous thrombolysis therapy in patients with pre-stroke disabilities


  • Intravenous thrombolysis (IVT) is safe in patients with pre-stroke disabilities and should not be withheld based solely on a pre-stroke Rankin Scale (pRS) score of 1–4.

Why this matters

  • Current guidelines for treatment of acute ischemic stroke (AIS) exclude recommendations on IVT and pre-stroke disabilities, and IVT rates in patients with pRS scores of ≥2 are low.

  • Because approximately 25% of patients presenting with AIS within the recommended treatment timeframe have pre-stroke disabilities, understanding the safety and effectiveness of IVT in these patients may improve treatment outcomes.