Acute migraine attacks are accompanied by reduced cortical thickness and volume in pain and migraine-related areas.
Why this matters
Although changes in cortical thickness in migraineurs has been reported, the presence of dynamic cortical and subcortical changes during migraine attacks is unknown. This important study is the first to report morphological magnetic resonance imaging changes during spontaneous migraine attacks compared to the inter-ictal phase. The findings reveal that migraine attacks are accompanied by transient reduced cortical thickness and volume in pain-related areas. This could represent a biomarker of acute pain in migraineurs which could help to evaluate antimigraine treatment effect.