Pain sensitivity is associated with resting-state gamma oscillations and functional connectivity in pain-related cortical regions of healthy individuals but not in patients with episodic migraine.
Why this matters
As the experience of pain is heavily influenced by genetic, environmental, and psychological factors, sensitivity to pain can vary drastically between individuals.
Previous studies have shown that the frequency of noxious-evoked neural oscillations in pain-related cortical regions may be related to inter-subject variability in pain perception. However, the relationship between spontaneous cortical activity and pain sensitivity remains elusive.
If spontaneous cortical activity can be used as a biomarker to ascertain an individual’s sensitivity to pain, it may be possible to determine the risk, severity, prognosis, and efficacy of treatment of clinical pain.