Pain sensitivity is associated with resting-state cortical activities in healthy individuals


  • Pain sensitivity is associated with resting-state gamma oscillations and functional connectivity in pain-related cortical regions of healthy individuals but not in patients with episodic migraine.

Why this matters

  • As the experience of pain is heavily influenced by genetic, environmental, and psychological factors, sensitivity to pain can vary drastically between individuals.

  • Previous studies have shown that the frequency of noxious-evoked neural oscillations in pain-related cortical regions may be related to inter-subject variability in pain perception. However, the relationship between spontaneous cortical activity and pain sensitivity remains elusive.  

    If spontaneous cortical activity can be used as a biomarker to ascertain an individual’s sensitivity to pain, it may be possible to determine the risk, severity, prognosis, and efficacy of treatment of clinical pain.