Pallido-nigro-luysian degeneration represents a distinct amyotrophic lateral sclerosis subtype

Takeaway

  • The pallido-nigro-luysian (PNL) system can be involved in the disease process of amyotrophic lateral sclerosis (ALS) through either non-selective multisystem degeneration or represent a distinct ALS subtype with selective degeneration.

Why this matters

    Classifying individuals based on their disease subtype may help with predicting disease progression, recognizing symptoms and improving the use of targeted treatment.