Pediatric multiple sclerosis severity score in a multicenter cohort

Takeaway

  • Pediatric-onset multiple sclerosis (POMS) patients have lower Expanded Disability Status Scale (EDSS) scores versus adult-onset disease patients, and the Pediatric Multiple Sclerosis Severity Score (Ped-MSSS) model might be more sensitive than the EDSS for evaluating disease severity in POMS patients.

Why this matters

  • Natural history studies suggest that pediatric-onset, compared with adult-onset multiple sclerosis has a relatively benign course; however there is increasing recognition of significant cognitive dysfunction in POMS.

  • Clarifying differences in clinical course and presentation between pediatric- and adult-onset multiple sclerosis could impact assessment and therapy development in this condition.