People with amyotrophic lateral sclerosis have a distinct gut microbiome compared with their healthy spouses

Takeaway

  • Compared with their healthy spouses, people with amyotrophic lateral sclerosis have more diverse gut microbiomes, including a higher number of taxa.

Why this matters ?

    Amyotrophic lateral sclerosis is a progressive neurodegenerative disease that is incurable and fatal. These important findings suggest that altered gut microbiome in these individuals could play a key role in its pathophysiology with implications for developing new therapeutics for amyotrophic lateral sclerosis that target the gut microbiome.