People with amyotrophic lateral sclerosis with cognitive dysfunction have more extreme cortical hyperexcitability

Takeaway

  • Cortical hyperexcitability is more conspicuous in people with amyotrophic lateral sclerosis with cognitive impairment.

Why this matters

    These novel findings provide valuable information about the pathogenesis of amyotrophic lateral sclerosis, as evidenced by cognitive and cortical excitability changes. It is hoped that transcranial magnetic stimulation parameters could act as outcome biomarkers in future therapeutic trials.