Chronic pain is not associated with consistent alterations in the brain’s response to noxious stimuli.
Why this matters
Functional neuroimaging is an indispensable tool for elucidating how people with chronic pain respond to painful stimuli. However, previous studies have reported conflicting results, necessitating the need for a quantitative meta-analysis to amalgamate existing data. These findings not only provide clarity on this topic, but also highlight the core set of pain-responsive areas that could act as novel therapeutic targets.