Pre-surgical thrombin generation is raised in people with glioblastoma but removal of the tumor causes a significant decrease in coagulation activation.
Why this matters
Almost a third of individuals with glioblastoma develop venous thromboembolism, and the risk is also higher in people with meningioma. Until recently, plasma thrombin generation could only be measured indirectly; the advent of calibrated automated thrombogram technology allows direct measurement of thrombin generation and, using this novel technology, the authors report that people with glioblastoma and meningioma have elevated thrombin generation. Pre-operative thrombin generation could be a potential biomarker for predicting venous thromboembolism risk in people with meningioma and glioblastoma.