Perfusion-weighted MRI and positron emission tomography to detect ischemic penumbra in acute stroke


  • This study validated multiple perfusion-weighted (PW) parameters vs the classical definition of penumbra by full quantitative 15O-PET and demonstrated that maximum time (Tmax) outperforms other PW parameters.

Why this matters?

  • The ischemic penumbra is the therapeutic target in acute clinical stroke therefore accurate identification of the ischemic penumbra is critical to identify patients that may respond to reperfusion therapies.