Peripapillary hyperreflective ovoid mass-like structures: A novel finding in Multiple Sclerosis


  • Peripapillary hyperreflective ovoid mass-like structures (PHOMS) are a novel finding in a proportion of patients with Multiple Sclerosis (MS).

Why this matters

  • Flattened ovoid nuclei have previously been observed adhering to the nerve fibers of optic discs in patients with MS, but with the advent of retinal optical coherence tomography (OCT) it has become possible to study these ovoid retinal structures (known as PHOMS) in closer detail.

  • The findings of this study provide a rationale for further research into the possible cause of PHOMS, such as impairment of the glymphatic system, which has not previously been explored as a possible MS pathway.