Phenotypic variants of posterior cortical atrophy and associated latent factors in dementia


  • Classification of posterior cortical atrophy (PCA) into four general phenotypic variants is unlikely to be clinically useful because most affected individuals show significant overlap in affected brain regions and symptoms.

Why this matters

  • Four phenotypic variants of PCA have been identified but the clinical relevance of these subtypes has not been established.

  • It is important for treating physicians to understand that phenotypic classification of PCA might not be valuable for accurate diagnosis, directing treatment and predicting outcomes in affected individuals.