Phosphorylated tau in Alzheimer’s disease

Takeaway

  • The phosphorylated tau (pTau) interactome in human Alzheimer’s disease (AD) brain has a comprehensive profile, including the interaction of novel proteins with the pTau pathway, which could uncover novel pathogenic mechanisms in AD.

Why this matters

  • Phosphorylated tau accumulation is a key feature of AD and causes a cascade of pathological processes including synaptic impairment and formation of neurofibrillary tangles (NFT); however, there is limited knowledge of the surrounding proteins with which tau interacts to mediate these processes.

  • The observation of novel protein pathways within the pTau interactome has important implications for directing further research in this area, including identification of new AD biomarkers and therapeutic targets for tauopathy treatment.