Phosphorylation and stability of DJ-1

Takeaway

  • This study indicates that the catalytic subunit alpha of protein kinase A (PKAcα) mediated formation of dimeric DJ-1 is important to regulate physiological concentrations of DJ-1, allowing DJ-1 to bypass cellular degradation systems.

Why this matters

    The post-translational modification of DJ-1 may be associated with its role in autosomal recessive early-onset parkinsonism, which should be further investigated in more pathophysiologically relevant animal models.