Physical activity linked to reduced cognitive decline independent of vascular risk factors.


  • Physical activity limits β-amyloid (Aβ) accumulation and cognitive decline in clinically normal older adults, independent of vascular risk factors; this suggests that engagement in exercise may present an opportunity to reduce the risk of Alzheimer’s disease (AD).

Why this matters

    Considerable evidence indicates that exercise has a protective effect on cognition in ageing adults, but it is not clear whether this is the result of a positive effect on vascular health or whether there is an impact on Aβ deposition. Understanding modifiable factors that can reduce the risk of AD is vital given the lack of successful pharmacological treatments.