Physical activity mediates the association between apolipoprotein E ε4 and cognition in early Parkinson's disease


  • Higher physical activity is linked to slower apolipoprotein E ε4-associated cognitive decline in early Parkinson's disease.

Why this matters ?

  • Cognitive impairment is a key contributor to functional disability and poor quality of life in Parkinson's disease. This study is the first to identify a potentially modifiable risk factor that could delay or prevent apolipoprotein E ε4-related cognitive decline in early Parkinson's disease.

  • Interventions that increase physical activity could help to delay cognitive decline in those with early Parkinson's disease carrying the apolipoprotein E ε4 allele.