Plasma ratio of amyloid beta as a potential biomarker to predict amyloid burden

Takeaway

  • Plasma ratio of amyloid beta (Aβ) 40 to 42 (Aβ40 /Aβ42) was predictive of amyloid burden in older adults with memory complaints using algorithms developed by either receiver operating characteristic (ROC) or classification and regression trees (CART) analyses.

Why this matters

  • The plasma ratio of Aβ40 /Aβ42 may serve as an economic and minimally-invasive biomarker to predict amyloid burden for clinical trial design and care of Alzheimer’s disease.