Polymorphisms in the vitamin D pathway affect relapse rate in children with multiple sclerosis

Takeaway

  • Polymorphisms in the vitamin D pathway are associated with 25-hydroxyvitamin

  • D (25]OH]D) levels and relapse rate in children with multiple sclerosis (MS), with a high vitamin D genetic risk score (vitDGRS) associated with a clinically relevant increased relapse rate.

Why this matters

  • The observation that vitDGRS identifies children at greater risk of relapse supports a causal role for vitamin D in the disease course; the findings could endorse the use of vitamin D supplementation to improve clinical outcomes in MS.