Potential dual and disease stage-dependent role for microglial in Alzheimer’s disease.

Takeaway

  • Microglial activation in established Alzheimer’s disease (AD) is linked to worsening of symptoms, yet in mild cognitive impairment (MCI) it is linked to reduced gray matter loss. A dual and disease-stage dependent role for microglia in AD may impact therapeutic strategies.

Why this matters

  • Microglial activation in established AD is linked to reduced memory function, but little is known about the activation status in relation to gray matter loss in MCI.