Precentral and postcentral gyri in the aging brain


  • Fractional anisotropy (FA) values in the precentral and postcentral gyri decrease over time, which is a significant indication of normal aging.

Why this matters

  • There is a scarcity of white matter imaging studies assessing brain microstructure during healthy aging despite their inherent value as baseline measures for neurological disease and injury models.

  • White matter values representing normal aging have potential significance as a baseline from which to assess brain disease mechanisms, particularly given the prevalence of neurodegenerative disorders in the aging population, along with evidence that brain abnormalities are often present before clinical presentation.