Predicting phenoconversion to Parkinson’s disease in those with atonia-free rapid eye movement sleep


  • People with more rapid eye movement (REM) sleep without atonia (RSWA) are more likely to develop a neurodegenerative disease such as Parkinson’s disease (PD), and they phenoconvert faster if they have increased anterior tibialis (AT) and submentalis (SM) muscle movement during RSWA.

Why this matters

  • Idiopathic REM sleep behavior disorder (iRBD) is associated with phenoconversion to early PD and mild cognitive impairment (MCI).

  • RSWA is a form of iRBD that is easier to identify clinically through phasic short duration high amplitude muscle activity and tonic muscle activity; however, it is unknown if any characteristics of RSWA are associated with phenoconversion.