Predicting risk of secondary progressive multiple sclerosis

Takeaway

  • Risk of conversion from relapsing-remitting to secondary progressive multiple sclerosis (SPMS) increased with age, duration of illness, number of recent relapses and worsening disability, while time on disease-modifying therapy (DMT) and improving disability were associated with lower risk.

Why this matters

    Identifying people with RRMS at high risk of SPMS provides an opportunity for earlier therapeutic intervention and the potential to improve patient outcomes.