Predicting the risk of cognitive decline in individuals with Parkinson’s disease


  • Retinal thickness, as measured by optical coherence tomography (OCT) at a single timepoint, could be a potential biomarker to predict cognitive decline in individuals with idiopathic Parkinson’s disease (iPD).

Why this matters

  • A common and disabling symptom of Parkinson’s disease (PD) is cognitive impairment, with up to 70% of individuals with PD affected with dementia after 10 years of disease onset. Some individuals experience earlier or more rapid cognitive deterioration, but cognitive decline in PD lack validated clinical biomarkers and are difficult to predict. However, many individuals with PD have abnormalities in their visual function which may be used to predict progression of cognitive disability. The results of this study may help identify the risk of motor and cognitive decline among individuals with PD.