Predictors of short-term outcome in disorders of consciousness


  • Standardized multimodal prognostic procedures in the clinical care of patients with prolonged disorders of consciousness (DoC) could help clinicians in identifying those patients who are most suitable for tailored rehabilitation programs and therapeutic interventions.

Why this matters

  • As DoC can last for longer than 28 days, reliable prognostic markers are needed to assist with decision-making about patient management.

  • Although recent research has shown the prognostic value of somatosensory evoked potentials (SEP) in the rehabilitative setting, and the Coma Recovery Scale-Revised (CRS-R) and electroencephalography (EEG) background activity in subacute phase, most of the evidence comes from single-center studies which have investigated individual clinical or neurophysiological prognostic markers and not the independent predictors.