Pregnancy and multiple sclerosis in high risk women


  • Pregnancy prior to symptom onset does not influence multiple sclerosis risk in genetically susceptible White females.

Why this matters

  • Gene-environment (GxE) interactions are thought to be important factors in complex disease risk; and despite studies of pregnancy and MS yielding conflicting results, none have directly explored interactions between pregnancy and genetic susceptibility for MS risk.

  • The lack of effect of pregnancy on symptom onset in high risk women highlights the need for further, more stringent research into this cohort; but lends support to similar studies, potentially providing reassurance to women of childbearing age with increased susceptibility to MS and the clinicians treating them.