Preoperative clinical and radiographic parameters predict craniopharyngiomas with BRAF mutations

Takeaway 

  • Supradiaphragmatic tumour location, absence of tumour calcification, and patient age >18 years predicts the presence of BRAF mutation with high sensitivity and specificity. 

Why this matters

    Identifying candidates for targeted BRAF V600E inhibitor therapy prior to surgery may reduce tumour burden and potentially reduce operative morbidity associated with craniopharyngioma excision.