Presence or absence of anti-GQ1b antibody in Bickerstaff brainstem encephalitis


  • Individuals with Bickerstaff brainstem encephalitis (BBE) who were anti-GQ1b antibody-positive exhibited distinct clinical features compared with individuals with anti-GQ1b antibody-negative BBE.

Why this matters

    BBE is a rare, immunological disease and considered a form of Fisher syndrome (FS). Characteristics of BBE include ataxia, consciousness disturbance, acute onset of external ophthalmoplegia, and subsequent infection. In a recent study, BBE was divided into two categories: definite and probable. Placement into these categories was based on the presence of typical or atypical clinical features of BBE and positivity or negativity for anti-GQ1b antibodies. The results of this study will help distinguish the clinical features of those with anti-GQ1b antibodies BBE from those without, which may help determine optimal treatments in the future.