Primary age-related tauopathy may be distinct from Alzheimer’s disease

Takeaway

  • Primary age-related tauopathy (PART) subjects show significantly slow rates of decline on measures of memory, language, and vision performance, and have lower apolipoprotein (APOE) ε4 allele frequency compared to Alzheimer’s disease (AD), supporting the hypothesis that PART and AD are distinct pathological entities.

Why this matters

  • Distinguishing PART from AD will be important for the clinical management of patients with cognitive impairment and for public healthcare planning.