Prion protein autoantibodies in people with PRNP mutations

Takeaway

  • Naturally occurring autoantibodies against prion protein (PrP) occur in the general population without clinical signs of prion disease.

Why this matters

    Although genetic prion diseases are associated with mutations in the human prion protein gene PRNP, the mechanisms by which these variants cause disease remain uncertain. These findings suggest that PrP autoantibodies are not associated with the onset of prion disease.