Progression of Parkinson’s disease mirrored by ongoing neuromelanin loss in the substantia nigra

Takeaway

  • Neuromelanin is progressively lost in the substantia nigra as people advance from prodromal to early and progressing clinical Parkinson’s disease over time.

Why this matters

    These novel findings could facilitate the assessment of disease progression in clinical trials of disease modification and ultimately lead to the development of new disease-modifying therapies.