Proposed biomarker of active focal to bilateral tonic-clonic seizures in temporal lobe epilepsy

Takeaway

  • People with focal to bilateral tonic-clonic seizures (FBTCS) in temporal lobe epilepsy (TLE) display increased thalamotemporal connectivity and reduced activation in the thalamus.

Why this matters

    Identifying a potential imaging biomarker for FBTCS provides a target for novel therapies for people with TLE, with the aim to reduce Sudden Unexpected Death in Epilepsy (SUDEP).