Pseudopalisades contain inflammatory mediators that impact the development of glioblastoma

Takeaway

  • Glioblastoma-associated microglia and macrophages (GAMMs) are the primary immune cells of hypoxic pseudopalisades (PPs), and these GAMMs may critically impact tumor dynamics and glioma cell invasion.

Why this matters

    Human glioblastoma (GBM) is characterized by the presence of hypoxic PPs; however, it is unclear how these PPs contribute to tumor progression.