Takeaway
Glioblastoma-associated microglia and macrophages (GAMMs) are the primary immune cells of hypoxic pseudopalisades (PPs), and these GAMMs may critically impact tumor dynamics and glioma cell invasion.
Why this matters
Human glioblastoma (GBM) is characterized by the presence of hypoxic PPs; however, it is unclear how these PPs contribute to tumor progression.