Radiation necrosis is unlikely without centrally restricted diffusion sign for radiosurgery-treated brain metastases

Takeaway

  • Inclusion of the centrally restricted diffusion sign in a multiparametric model improves accuracy for the discrimination of radiation necrosis from tumor progression in metastases treated with stereotactic radiosurgery.

Why this matters

  • Differentiation of radiation necrosis from tumor progression in brain metastases treated with stereotactic radiosurgery is difficult.

  • This novel study demonstrates high negative predictive value of the centrally restricted diffusion sign and good inter-reader agreement, highlighting its potential use in clinical practice for differentiation of radiation necrosis from tumor progression.