Radiological and functional outcomes associated with bridging therapy in stroke with unknown onset


  • Bridging therapy (BT), compared with direct mechanical thrombectomy (MT), was associated with better 3-month functional outcomes and a higher successful recanalization rate in stroke patients with unknown onset with intracranial internal carotid artery (ICA), M1-segment middle cerebral artery (M1-MCA), or M2-segment MCA (M2-MCA) occlusion and 10-Point Alberta Stroke Program Early CT Score (ASPECTS; 10PA), who received endovascular therapy (EVT) within 6 hours of symptom recognition or awakening.

Why this matters

    No data are currently available concerning safety and efficacy of BT in stroke patients with unknown symptom onset and normal computed tomography (CT) scan. Understanding clinical outcomes may improve treatment in this patient population.