Rate of tau aggregation in people with Alzheimer’s disease

Takeaway

  • This 2-year longitudinal study analyzing patients with Alzheimer’s disease (AD) found that the tau accumulation rate is greater in females, younger amyloid-b-positive individuals, and people with a higher baseline tau load. Amyloid-b accumulation is greater in APOE e4 carriers and older individuals.

Why this matters

    Increased knowledge about mechanisms behind tau accumulation could guide clinical trial designs and development of therapies for AD.