Real-life gait measures with wearable sensors correlated with cerebellar ataxia disease severity

Takeaway

  • A set of highly sensitive gait variability measures correlated with disease severity in patients with degenerative cerebellar ataxia (DCA) in supervised clinical settings, as well as in the real-life setting, being potential ecologically valid biomarkers in DCA.

Why this matters

  • Studies which measured real-life ataxic gait in patients with DCA were lacking and such measurement was complicated by the inherently higher variability of ataxic gait in the real-life setting.

  • Real-life ataxic gait is a better measure of patients’ day-to-day motor function and serves as a potential ecologically valid biomarker in DCA clinical trials.