Reduced medial temporal lobe connectivity linked to poor cognition in early Alzheimer’s disease

Takeaway

  • The integrity of critical white matter tracts is linked to decreased functional connectivity in mild cognitive impairment but not in cognitively normal individuals.

Why this matters

    These novel findings increase our understanding of the mechanisms underlying cognitive decline in early stages of Alzheimer’s disease. The differential effects of amyloid-ß pathology on critical memory systems suggests that stage-specific functional connectivity could be a marker for disease progression.