Reduced survival in people with amyotrophic lateral sclerosis and minor allele of the UNC13A gene

Takeaway

  • The minor allele of the rs12608932 polymorphism in UNC13A gene is associated with reduced survival, lower respiratory function and higher age at symptom onset in people with amyotrophic lateral sclerosis (ALS).

Why this matters ?

    Identification of disease modifiers, such as common genetic variants, can help to tailor treatments to individuals with ALS.