Regional brain volumes, disability progression and cognitive function in multiple sclerosis


  • Grey (GM) and white matter (WM) volumes in specific brain regions may predict cognitive performance and disability progression after one year in patients with primary progressive multiple sclerosis (PPMS).

Why this matters

  • There is little evidence regarding the impact of specific brain regions on cognitive function and disease progression in PPMS despite theories suggesting their involvement in these processes.

  • Specific brain regional volumes may act as PPMS disease progression predictors, allowing for individually tailored treatment which could improve long-term outcomes for patients, and may benefit research into potential treatments for discrete MS subtypes.