Regional transcriptional profiling of Parkinson’s disease

Takeaway

  • Network diffusion modelling (NDM) suggests that the substantia nigra is a likely seed region of Parkinson’s disease (PD) pathology from where atrophy spreads, and that immune-related and lysosomal PD risk factor genes can predict seed regions.

Why this matters

    Early disease sites may be susceptible to neuroinflammation and lysosomal dysfunction, contributing to early disease propagation; these genes and pathologies may be useful as combined genetic and imaging biomarkers of PD.