Relationship between amyloid, tau, neurodegeneration profiles and long-term cognitive outcomes


  • Longitudinal analysis of cognitively normal individuals with different amyloid, tau and neurodegeneration profiles indicates that abnormalities in all three of these biomarkers at baseline is required to predict subsequent cognitive decline.

Why this matters ?

  • The amyloid/tau/neurodegeneration (ATN) classification schema for pre-clinical and symptomatic Alzheimer disease (AD) forms the basis of the 2018 National Institute on Aging (NIA) and Alzheimer’s Association (NIA-AA) research framework, and data from the current study will have important implications for its practical implementation.