Relationship between apathy scores and brain metabolism in people with amyotrophic lateral sclerosis

Takeaway

  • People with amyotrophic lateral sclerosis (ALS) who had increased apathy scores, had lower metabolism in regions of the brain involved in the apathy circuitry, including the prefrontal cortex and insula.

Why this matters

    This is the first study to assess brain 18F-2-fluoro-2-deoxy-D-glucose Positron Emission Tomography (18F-FDG-PET) correlates of apathy in people with ALS and can be used to guide future targeted treatments.