Relationship between brain amyloid beta and cognition


  • Amyloid beta (Aβ) affects cognition independently of age, sex, education, hippocampal volume, and markers of cerebrovascular small vessel disease (CSVD) in patients with cognitive impairment and no dementia (CIND) and Alzheimer’s dementia (AD), and there is a significant interaction between global standardized uptake value ratio (SUVR) and higher burden of white matter hyperintensities (WMH) in CIND, suggesting that WMH may be an important target to prevent cognitive dysfunction in preclinical AD.

Why this matters

    Both brain Aβ and CSVD are major contributors to cognitive impairment and dementia, but there are conflicting results regarding their relationship, and the relationship between Aβ and WMH. Understanding these interactions may help improve treatments for AD.