Relationship between CAA-SVD score and cortical microinfarcts in cerebral amyloid angiopathy

Takeaway

  • In patients with probable cerebral amyloid angiopathy (CAA), presence of cortical microinfarcts (CMIs) was significantly associated with total CAA-small vessel disease (SVD) score, thus the presence of CMIs plus a high CAA-SVD score may indicate more severe amyloid-associated changes in vasculopathy.

Why this matters

    The CAA-SVD score has been proposed to quantify total burden of SVD on magnetic resonance imaging (MRI) for patients with CAA, but the relationship of this scoring system to CAA pathology and CMIs is not fully understood. Elucidating this relationship will aid in improving patient outcomes.