Relationship between central hypersomnias, fatigue, and sleepiness in multiple sclerosis


  • Over 50% of patients with multiple sclerosis (MS) who had fatigue and sleepiness were also diagnosed with central hypersomnia, suggesting that polysomnography, mean sleep latency test (MSLT), and 24-hour bed rest tests may be useful in this patient population.

Why this matters

    While fatigue is a common and troubling symptom of MS, the role of sleep disorders in MS – specifically central hypersomnias – has not been systematically studied. Results of this study identify a relationship between MS and central hypersomnias, potentially advocating for new clinical trials for pharmacological stimulants in patients with MS and fatigue.